必发彩票,必发彩票开户,必发彩票注册,必发彩票代理,必发彩票官网,必发彩票网址,必发彩票交流群

Baidu

必发彩票中国医学科学院北京协和医学院血液病医院(血液学研究所)(以下简称“院所”)由中国血液学创始人邓家栋教授创建于1957年。七十年代迁往四川,1982年重新迁回天津。   90年代以来,随着我国血液学事业的发展和医疗市场的变化,院所不断开拓创新,必发彩票谋求血液学事业的新发展。从容不从众,追求创新,精髓不变是我们的办院方针。为把医院做“特”,科研做“精”,我们改“大所小院”为“大院小所”,由过去200张床位的“小综合”,发展为600余张床位的血液病“大专科”,由过去一个大血液内科发展为按病种和功能设置的12个临床中心的专科医院;以实验血液学国家重点实验室为龙头,围绕实验血液学和干细胞研究凝炼研究方向,建立了精干的基础研究队伍。

 
邱录贵课题组在Clinical Cancer Research期刊发表文章

  我所邱录贵课题组在Clinical Cancer Research期刊发表文章“ The impact of clone size on the prognostic value of chromosome aberrations by fluorescence in situ hybridization in multiple myeloma”。

  Abstract

  

PURPOSE:

  Accumulating evidence indicates that intratumor heterogeneity is prevalent in multiple myeloma and that a collection of multiple, genetically distinct subclones are present within the myeloma cell population. It is not clear whether the size of clonal myeloma populations harboring unique cytogenetic abnormalities carry any additional prognostic value.

EXPERIMENTAL DESIGN:

  We analyzed the prognostic impact of cytogenetic aberrations by fluorescence in situ hybridization at different cutoff values in a cohort of 333 patients with newly diagnosed myeloma and 92 patients with relapsed myeloma.

RESULTS:

  We found that nearly all IgH-related arrangements were observed in a large majority of the purified plasma cells; however, 13q deletion, 17p deletion, and 1q21 amplification appeared in different percentages within the malignant plasma cell population. Based on the size of subclones carrying these cytogenetic aberrations, the patients were divided into four groups: 0%-10%, 10.5%-20%, 20.5%-50%, and >50%. Receiver-operating characteristics analysis was applied to determine the optimal cutoff value with the greatest differential survival and showed that the most powerful clone sizes were 10% for 13q deletion, 50% for 17p deletion, and 20% for 1q21 gains, which provided the best possible cutoffs for predicting poor outcomes.

CONCLUSIONS:

  Our study indicated that the impact of clone size on prognostic value varies between specific genetic abnormalities. Prognostic value was observed for even a subgroup of plasma cells harboring the cytogenetic aberration of 13q deletion and 1q21 gains; however, 17p deletion displayed the most powerful cutoff for predicting survival only if the predominant clones harbored the abnormality.

查阅原文链接

   
网站导航 | 联系我们 | 使用帮助 | 网站声明


必发彩票www.munasprok.com版权所有  技术支持:北方网
  备案序号:津ICP备05001070号
建议使用IE6.0以上浏览器,分辨率1024*768