必发彩票,必发彩票开户,必发彩票注册,必发彩票代理,必发彩票官网,必发彩票网址,必发彩票交流群

Baidu

必发彩票中国医学科学院北京协和医学院血液病医院(血液学研究所)(以下简称“院所”)由中国血液学创始人邓家栋教授创建于1957年。七十年代迁往四川,1982年重新迁回天津。   90年代以来,随着我国血液学事业的发展和医疗市场的变化,院所不断开拓创新,必发彩票谋求血液学事业的新发展。从容不从众,追求创新,精髓不变是我们的办院方针。为把医院做“特”,科研做“精”,我们改“大所小院”为“大院小所”,由过去200张床位的“小综合”,发展为600余张床位的血液病“大专科”,由过去一个大血液内科发展为按病种和功能设置的12个临床中心的专科医院;以实验血液学国家重点实验室为龙头,围绕实验血液学和干细胞研究凝炼研究方向,建立了精干的基础研究队伍。

 
杨仁池、张磊课题组在Leukemia期刊发表原发性血小板增多症相关研究文章

  杨仁池张磊课题组在Leukemia期刊发表文章“Analysis of calreticulin mutations in Chinese patients with essential thrombocythemia: clinical implications in diagnosis, prognosis and treatment

  杨仁池、张磊团队通过对436例原发性血小板增多症(ET)患者的JAK2 V617FMPL及新发现基因CALR的突变情况的研究,发现中国ET患者的MPL基因突变率低于欧美患者,并在ET患者中首次报道了CALR基因的获得性点突变。CALR基因突变患者的无血栓生存率显著高于JAK2 V617F突变患者。研究还发现不同的CALR基因突变亚型之间在临床特点上也存在差异。JAK2 V617F突变可以作为开始抗血小板及减低血小板治疗的分子标志,而单独存在CALR基因突变不足以成为开始药物治疗的指标。以上结果表明CALR基因突变和JAK2 V617F突变在中国ET患者的诊断、预后判断和指导治疗中有重要价值。

  

  Abstract

  Recently, discovery of calreticulin (CALR) mutations fills the molecular diagnostic gap in essential thrombocythemia (ET). However, the prevalence of CALR mutations has not been reported in Asian patients, and its therapeutic implications have not yet been evaluated. We studied profiles of JAK2 V617F, MPL and CALR mutations in 436 Chinese ET patients. Compared with Caucasian patients, Chinese patients had a lower frequency of MPL mutations. We reported the first somatic point mutation in CALR in ET patients. The lower frequency of thrombosis in CALR-mutated patients was most likely due to the low thrombotic rate in type 2 CALR-mutated patients. Although no difference concerning fibrotic transformation was found between CALR-mutated and V617F+ ET, CALR-mutated patients had a higher degree of reticulin deposition. The difference was mostly ascribed to the higher rate of grade 1 reticulin deposition in type 1 CALR-mutated patients. Combination use of antiplatelet and cytoreductive agents decreased the risk of thrombosis in V617F+ patients, but not in CALR-mutated cases. We confirm the value of CALR mutations in the diagnosis and prognosis of ET in Chinese patients, and provide new evidence for making treatment strategies based on molecular markers.

  点击阅读全文:

  手机阅读

  

  

  

   
网站导航 | 联系我们 | 使用帮助 | 网站声明


必发彩票www.munasprok.com版权所有  技术支持:北方网
  备案序号:津ICP备05001070号
建议使用IE6.0以上浏览器,分辨率1024*768