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必发彩票中国医学科学院北京协和医学院血液病医院(血液学研究所)(以下简称“院所”)由中国血液学创始人邓家栋教授创建于1957年。七十年代迁往四川,1982年重新迁回天津。   90年代以来,随着我国血液学事业的发展和医疗市场的变化,院所不断开拓创新,必发彩票谋求血液学事业的新发展。从容不从众,追求创新,精髓不变是我们的办院方针。为把医院做“特”,科研做“精”,我们改“大所小院”为“大院小所”,由过去200张床位的“小综合”,发展为600余张床位的血液病“大专科”,由过去一个大血液内科发展为按病种和功能设置的12个临床中心的专科医院;以实验血液学国家重点实验室为龙头,围绕实验血液学和干细胞研究凝炼研究方向,建立了精干的基础研究队伍。

 
副所院长王建祥带领的研究团队在《Blood》发表新成果

  副所院长王建祥带领的研究团队在国际血液学领域的核心期刊《Blood》发表题为"TBLR1 fuses to retinoid acid receptor alpha in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia”的研究论文。

   英文摘要

   The majority of acute promyelocytic leukemia (APL) cases are characterized by PML-RARα fusion gene. Although PML-RARα fusion gene can be detected in more than 98% of APL cases, RARα is also found to be fused with other partner genes, which are also related to all-trans retinoic acid (ATRA) dependent transcriptional activity and cell differentiation. In this study, we identified a novel RARα fusion gene, TBLR1-RARα (GenBank KF589333), in a rare case of APL with a t(3;17)(q26;q21), t(7;17)(q11.2;q21) complex chromosomal rearrangement. To our knowledge, TBLR1-RARα is the tenth RARα chimeric gene which has been reported up to now. TBLR1-RARα contained the B-F domains of RARα, exhibited a distinct subcellular localization. It could form homodimers and also heterodimers with RXRα. As a result, TBLR1-RARα exhibited diminished transcriptional activity by recruitment of more transcriptional corepressors compared with RARα. In the presence of pharmacological doses of ATRA, TBLR1-RARα could be degraded and its homodimerization was abrogated. Moreover, when treated with ATRA, TBLR1-RARα could mediate the dissociation and degradation of transcriptional corepressors, consequent transactivation of RARα target genes and cell differentiation induction in a dose- and time-dependent manner.

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